ABOUT AUTHOR Suhas.S Siddheshwar, Ganesh.A.Waghmare, Prashant.B.Wadghule, Dattaprasad.N.Vikhe, Prajakta.S.Varpe Pravara Rural College of Pharmacy, A/P-Loni, Tal-Rahata, Dist. Ahmednagar, India-413736 Abstract Traditionally nearly 40% of the new chemical entities identified by pharmaceutical industry screening programmes have failed to be developed because of low solubility and low permeability which make formulation difficult or even impossible. The solubility issues complicating the delivery of many existing drugs.

1. Bcs Class 4 Compounds

The solubility issues complicating the delivery of many existing drugs. The various tradition and novel technique that can be used for bioavability enhancement of BCS class 4 drugs are discussed in this article. FDA has issued a final guidance entitled Waiver of In-vivo Bioavailability and Bioequivalence Studies for Immediate Release Solid Oral Dosage Forms Based on a Biopharmaceutics Classification System.

Dissolution Enhancement of BCS Class 4 Dssrugs Using Quality by Design Approach with Solid Dispersion Technique - Free download as PDF File (.pdf), Text File (.txt) or read online for free. Solid dispersion is one of the vastly accepted and practically economical processes in bioavailability enhancement study.

Bcs Class 4 Compounds

The various tradition and novel technique that can be used for bioavability enhancement of BCS class 4 drugs are discussed in this article. The traditional techniques discussed in this article includes use of co-solvents, hydrotopymicronization, amorphous forms, chemical modification of drug, use of surfactant, complexation.nano-nization.use of prodrug, alternation of pH, use of ppt.inhibitor solvent deposition. In case of novel drug delivery technologies depends upon the development in recent year for bio-avability enhancement of poor soluble-poor permeable are size reduction. Lipid based deliven- system, micellar techniques, micro-particle techniques.